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The result of his insight would eventually reshape the treatment of metabolic disease worldwide, leading to a class of drugs that now includes Ozempic, Wegovy, Mounjaro, and Zepbound—medications that have been called the most important advance in metabolic health since insulin itself
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Non-adrenergic, non-cholinergic (NANC) neurons located in the pelvic plexus and pelvic nerves express neuronal nitric oxide synthase (nNOS) and release NO directly into adjacent vascular smooth muscle cells (VSMCs)
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